Institute of Plant Molecular and Cellular Biology, CSIC–Polytechnical University of Valencia
He is a Group Leader since 1999, when he became Staff Scientist of the Spanish Research Council. He studied Chemistry in the University of Seville and obtained his PhD in Biochemistry in 1990 for his work on sulfate assimilation and cysteine biosynthesis in green algae. As a postdoc, he joined the AgBiotech Center for Agricultural Molecular Biology (NJ, U.S.A)), where he studied the biosynthesis and action of salicylic acid in the activation of Systemic Acquired Resistance in pathogen-challenged plants under the supervision of Prof. Ilya Raskin. After four years in the AgBiotech, he joined Sánchez-Serrano´s lab at the National Center of Biotechnology (Madrid, Spain) to work in the functional characterization of jasmonate biosynthesis and action in wound-activated responses in plants. Work in the León Lab is focused in the signaling events allowing functional connections between developmental programs and defense responses to stress. Special emphasis is placed on the role of nitric oxide in coordination with abscisic acid, gibberellins, salicylates and jasmonates in regulating developmental processes, such as seed germination and photomorphogenesis, as well as responses to stress, such as tolerance to drought or extreme temperatures. The lab is also deeply involved in the study of nitric oxide-related posttranslational modifications, such as nitration of tyrosines and S-nitrosylation of cysteines, of key signaling proteins involved in hormone-mediated regulation.
Gibbs et al (2014) Nitric oxide sensing in plants is mediated by proteolytic control of group VII ERF transcription factors. Mol Cell 53: 369-379.
Lozano-Juste J, Leon J (2011) Nitric Oxide Regulates DELLA Content and PIF Expression to Promote Photomorphogenesis in Arabidopsis. Plant Physiol. 156: 1410-1423.
Lozano-Juste J et al (2011) In vivo protein tyrosine nitration in Arabidopsis thaliana. J Exp Bot. 62: 3501-3517.